Ontology highlight
ABSTRACT:
SUBMITTER: Pryor JM
PROVIDER: S-EPMC3197757 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Pryor John M JM Washington M Todd MT
DNA repair 20111004 11
Rev1 is a eukaryotic DNA polymerase that rescues replication forks stalled at sites of DNA damage by inserting nucleotides opposite the damaged template bases. Yeast genetic studies suggest that Rev1 plays an important role in rescuing replication forks stalled at one of the most common forms of DNA damage, an abasic site; however, steady state kinetic studies suggest that an abasic site acts as a significant block to nucleotide incorporation by Rev1. Here we examined the pre-steady state kineti ...[more]