GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3201775 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Publications
GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis.
Chen Lichao L McKenna James T JT Leonard Michael Z MZ Yanagawa Yuchio Y McCarley Robert W RW Brown Ritchie E RE
Neuroreport 20100201 3
Gamma-aminobutyric acid (GABA) ergic neurons are important for controlling sleep and wakefulness but are difficult to identify, limiting their study. Knock-in mice with GABAergic neurons labeled by expression of green fluorescent protein (GFP) under control of the glutamate decarboxylase 67 (GAD67) promoter are now extensively used in neuroscience. However, it is unknown whether these mice have a normal sleep phenotype. Compared with wild-type control mice, GAD67-GFP knock-in mice had the same a ...[more]
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