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ABSTRACT:
SUBMITTER: Beesley S
PROVIDER: S-EPMC7668169 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Beesley Stephen S Kim Dae Wook DW D'Alessandro Matthew M Jin Yuanhu Y Lee Kwangjun K Joo Hyunjeong H Young Yang Y Tomko Robert J RJ Faulkner John J Gamsby Joshua J Kim Jae Kyoung JK Lee Choogon C
Proceedings of the National Academy of Sciences of the United States of America 20201026 45
The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the activator complex in the feedback loop. Although this temporal manifestation of the feedback inhibition is the direct consequence of PER's cytoplasmic trafficking before nuclear entry, how this spatia ...[more]