Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez-Mateos EM
PROVIDER: S-EPMC3204080 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Jimenez-Mateos Eva M EM Bray Isabella I Sanz-Rodriguez Amaya A Engel Tobias T McKiernan Ross C RC Mouri Genshin G Tanaka Katsuhiro K Sano Takanori T Saugstad Julie A JA Simon Roger P RP Stallings Raymond L RL Henshall David C DC
The American journal of pathology 20110923 5
When an otherwise harmful insult to the brain is preceded by a brief, noninjurious stimulus, the brain becomes tolerant, and the resulting damage is reduced. Epileptic tolerance develops when brief seizures precede an episode of prolonged seizures (status epilepticus). MicroRNAs (miRNAs) are small, noncoding RNAs that function as post-transcriptional regulators of gene expression. We investigated how prior seizure preconditioning affects the miRNA response to status epilepticus evoked by intra-a ...[more]