Ontology highlight
ABSTRACT:
SUBMITTER: Lai PY
PROVIDER: S-EPMC3214907 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Lai P-Y PY Wang C-Y CY Chen W-Y WY Kao Y-H YH Tsai H-M HM Tachibana T T Chang W-C WC Chung B-c BC
Cell death and differentiation 20110513 12
SF-1 (Steroidogenic Factor 1, NR5A1) is a tissue-specific transcription factor critical for the growth, development and differentiation of steroidogenic and a few other endocrine tissues. But how SF-1 regulates cell growth is not entirely clear. Here we found that SF-1 was localized to the centrosome in addition to the nucleus, and SF-1 depletion by shRNA caused centrosome over-duplication, aberrant mitosis and genomic instability, leading to a reduction of cell number. Centrosome amplification ...[more]