Ontology highlight
ABSTRACT:
SUBMITTER: Kim MK
PROVIDER: S-EPMC3410387 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kim Mi Kyung MK Dudognon Charles C Smith Susan S
EMBO reports 20120615 8
CPAP--a gene mutated in primary microcephaly--is required for procentriole formation. Here we show that CPAP degradation and function is controlled by the poly(ADP-ribose) polymerase tankyrase 1. CPAP is PARsylated by tankyrase 1 in vitro and in vivo. Overexpression of tankyrase 1 leads to CPAP proteasomal degradation, preventing centriole duplication, whereas depletion of tankyrase 1 stabilizes CPAP in G1, generating elongated procentrioles and multipolarity. Tankyrase 1 localizes to centrosome ...[more]