Ontology highlight
ABSTRACT:
SUBMITTER: Rella MR
PROVIDER: S-EPMC3220948 | biostudies-other | 2007 Jan
REPOSITORIES: biostudies-other
Rella Maria Rosaria MR Williard Paul G PG
The Journal of organic chemistry 20070101 2
Representative Boc-protected and acetyl-protected peptide methyl esters bearing alkyl side chains undergo effective oxidation using methyl(trifluoromethyl)dioxirane (1b) under mild conditions. We observe a protecting group dependency in the chemoselectivity displayed by the dioxirane 1b. N-Hydroxylation occurs in the case of the Boc-protected peptides, and side chain hydroxylation takes place in the case of acetyl-protected peptides. Both are attractive transformations since they yield derivatiz ...[more]