Ontology highlight
ABSTRACT:
SUBMITTER: Wong D
PROVIDER: S-EPMC3228452 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Wong Dennis D Bach Horacio H Sun Jim J Hmama Zakaria Z Av-Gay Yossef Y
Proceedings of the National Academy of Sciences of the United States of America 20111115 48
Mycobacterium tuberculosis (Mtb) pathogenicity depends on its ability to inhibit phagosome acidification and maturation processes after engulfment by macrophages. Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPase) machinery, a multisubunit protein complex in the phagosome membrane that drives luminal acidification. Furthermore, we show that the macrophage class C vacuolar protein sorting complex, a key regu ...[more]