Ontology highlight
ABSTRACT:
SUBMITTER: Siegel AM
PROVIDER: S-EPMC3228524 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Siegel Andrea M AM Heimall Jennifer J Freeman Alexandra F AF Hsu Amy P AP Brittain Erica E Brenchley Jason M JM Douek Daniel C DC Fahle Gary H GH Cohen Jeffrey I JI Holland Steven M SM Milner Joshua D JD
Immunity 20111101 5
STAT3 transcription factor signaling in specific T helper cell differentiation has been well described, although the broader roles for STAT3 in lymphocyte memory are less clear. Patients with autosomal-dominant hyper-IgE syndrome (AD-HIES) carry dominant-negative STAT3 mutations and are susceptible to a variety of bacterial and fungal infections. We found that AD-HIES patients have a cell-intrinsic defect in the number of central memory CD4(+) and CD8(+) T cells compared to healthy controls. Nai ...[more]