Ontology highlight
ABSTRACT:
SUBMITTER: Jeong KW
PROVIDER: S-EPMC3230772 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Jeong Kwang Won KW Kim Kyunghwan K Situ Alan Jialun AJ Ulmer Tobias S TS An Woojin W Stallcup Michael R MR
Nature structural & molecular biology 20111113 12
Many co-regulator proteins are recruited by DNA-bound transcription factors to remodel chromatin and activate transcription. However, mechanisms for coordinating actions of multiple co-regulator proteins are poorly understood. We demonstrate that multiple protein-protein interactions by the protein acetyltransferase TIP60 are required for estrogen-induced transcription of a subset of estrogen receptor alpha (ERα) target genes in human cells. Estrogen-induced recruitment of TIP60 requires direct ...[more]