Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC2783526 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Sun Yingli Y Jiang Xiaofeng X Xu Ye Y Ayrapetov Marina K MK Moreau Lisa A LA Whetstine Johnathan R JR Price Brendan D BD
Nature cell biology 20090927 11
DNA double-strand break (DSB) repair involves complex interactions between chromatin and repair proteins, including Tip60, a tumour suppressor. Tip60 is an acetyltransferase that acetylates both histones and ATM (ataxia telangiectasia mutated) kinase. Inactivation of Tip60 leads to defective DNA repair and increased cancer risk. However, how DNA damage activates the acetyltransferase activity of Tip60 is not known. Here, we show that direct interaction between the chromodomain of Tip60 and histo ...[more]