Modulating inhibitory ligand-gated ion channels.
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ABSTRACT:
SUBMITTER: Cascio M
PROVIDER: S-EPMC3231573 | biostudies-other | 2006
REPOSITORIES: biostudies-other
Publications
The glycine and gamma-aminobutyric acid receptors (GlyR and GABA(A)R, respectively) are the major inhibitory neurotransmitter-gated receptors in the central nervous system of animals. Given the important role of these receptors in neuronal inhibition, they are prime targets of many therapeutic agents and are the object of intense studies aimed at correlating their structure and function. In this review, the structure and dynamics of these and other homologous members of the nicotinicoid superfam ...[more]
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