Ontology highlight
ABSTRACT:
SUBMITTER: Garbers C
PROVIDER: S-EPMC3234812 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Garbers Christoph C Thaiss Wolfgang W Jones Gareth W GW Waetzig Georg H GH Lorenzen Inken I Guilhot Florence F Lissilaa Rami R Ferlin Walter G WG Grötzinger Joachim J Jones Simon A SA Rose-John Stefan S Scheller Jürgen J
The Journal of biological chemistry 20111011 50
IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most pathophysiological conditions are characterized by a molar excess of serum sIL-6R over IL-6 characterized by free IL-6 and IL-6 found in IL-6·sIL-6R complexes allowing both classic and trans-signaling. Sur ...[more]