Ontology highlight
ABSTRACT:
SUBMITTER: Chojnacki A
PROVIDER: S-EPMC6741977 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Chojnacki Andrew A Shimazaki Takuya T Gregg Christopher C Weinmaster Gerry G Weiss Samuel S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030301 5
Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs. Disruption of Notch1 using antisense or a gamma-secretase inhibitor demonstrated a requirement for Notch1 in the maintenance and proliferation of NSCs. Ciliary neurotrophic factor (CNTF) activation of gp130 in NSCs rapidly increased Notch1 expression. NOTCH1 activation, indicated ...[more]