Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan S
PROVIDER: S-EPMC3243500 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Narayanan Saravanakumar S Arthanari Haribabu H Wolfe Michael S MS Wagner Gerhard G
The Journal of biological chemistry 20111013 51
DISC1 (Disrupted in schizophrenia-1) plays essential roles in neuronal proliferation, neuronal migration and axon guidance and has been implicated in schizophrenia and related psychiatric disorders. DISC1 forms a functional complex with nuclear distribution element-like protein-1 (NDEL1), a key component that regulates microtubule organization during cell division and neuronal migration. DISC1 polymorphisms at the binding interface of DISC1-NDEL1 complex have been implicated in schizophrenia. Ho ...[more]