Dataset Information
Disrupted circadian rhythms in a mouse model of schizophrenia
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sheena Lee
PROVIDER: E-MEXP-3493 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Disrupted circadian rhythms in a mouse model of schizophrenia.
Current biology : CB 20120119 4
Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia [1] and often precedes related symptoms [2]. However, mechanistic basis for this association remains unknown. Therefore, we investigated the circadian phenotype of blind-drunk (Bdr), a mouse model of synaptosomal-associated protein (Snap)-25 exocytotic disruption that displays schizophrenic endophenotypes modulated by prenatal factors and reversible by antipsychotic treatment [3, ...[more]
