Ontology highlight
ABSTRACT:
SUBMITTER: Sangaletti S
PROVIDER: S-EPMC3260886 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Sangaletti Sabina S Tripodo Claudio C Cappetti Barbara B Casalini Patrizia P Chiodoni Claudia C Piconese Silvia S Santangelo Alessandra A Parenza Mariella M Arioli Ivano I Miotti Silvia S Colombo Mario P MP
The American journal of pathology 20111011 6
Fibrosis results from inflammatory tissue damage and impaired regeneration. In the context of bleomycin-induced pulmonary fibrosis, we demonstrated that the matricellular protein termed secreted protein acidic and rich in cysteine (SPARC) distinctly regulates inflammation and collagen deposition, depending on its cellular origin. Reciprocal Sparc(-/-) and wild-type (WT) bone marrow chimeras revealed that SPARC expression in host fibroblasts is required and sufficient to induce collagen fibrosis ...[more]