Dataset Information

Contrasting effects of physical wear on elution of two antibiotics from orthopedic cement.

ABSTRACT: The use of antibiotics as a supplement to bone cement for the purposes of providing a local release of antibiotics is common practice in arthroplasty surgery and the kinetics of elution of the antibiotics in such systems have been investigated previously. However, in these previous studies no account was taken of the potential effects that wear may have on the elution kinetics of the antibiotic. Here, we have modified an existing wear testing rig to allow the simultaneous study of the elution kinetics of bone cement samples containing antibiotics being subjected to immersion only and immersion and conjoint wear. The results show contrasting effects with two commonly used antibiotics. Bone cement containing daptomycin showed no substantial change in antibiotic elution due to wear, while cement containing gentamicin (the most commonly used antibiotic in this application) in contrast demonstrated a substantial reduction in the rate of antibiotic elution when wear was applied. Scanning electron microscopy revealed a possible explanation for these diverse results, due to wear-induced "sealing" of the surface in conjunction with the crystal morphology of the antibiotic.

SUBMITTER: Dodds S

PROVIDER: S-EPMC3294895 | biostudies-other | 2012 Mar

REPOSITORIES: biostudies-other

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Contrasting effects of physical wear on elution of two antibiotics from orthopedic cement.

Dodds S S Smith T J TJ Akid R R Stephenson J J Nichol T T Banerjee R D RD Stockley I I Townsend R R

Antimicrobial agents and chemotherapy 20111212 3

The use of antibiotics as a supplement to bone cement for the purposes of providing a local release of antibiotics is common practice in arthroplasty surgery and the kinetics of elution of the antibiotics in such systems have been investigated previously. However, in these previous studies no account was taken of the potential effects that wear may have on the elution kinetics of the antibiotic. Here, we have modified an existing wear testing rig to allow the simultaneous study of the elution ki ...[more]

PMID: 22155831

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Project description:BACKGROUND:Accelerometers are widely used to measure sedentary time and daily physical activity (PA). However, data collection and processing criteria, such as non-wear time rules might affect the assessment of total PA and sedentary time and the associations with health variables. The study aimed to investigate whether the choice of different non-wear time definitions would affect the outcomes of PA levels in youth. METHODS:Seventy-seven healthy youngsters (44 boys), aged 10-17?years, wore an accelerometer and kept a non-wear log diary during 4 consecutives days. We compared 7 published algorithms (10, 15, 20, 30, 60?min of continuous zeros, Choi, and Troiano algorithms). Agreements of each algorithm with the log diary method were assessed using Bland-Altmans plots and by calculating the concordance correlation coefficient for repeated measures. RESULTS:Variations in time spent in sedentary and moderate to vigorous PA (MVPA) were 30 and 3.7%. Compared with the log diary method, greater discrepancies were found for the algorithm 10?min (p?<?0.001). For the time assessed in sedentary, the agreement with diary was excellent for the 4 algorithms (Choi, r?=?0.79; Troiano, r?=?0.81; 30?min, r?=?0.79; 60?min, r?=?0.81). Concordance for each method was excellent for the assessment of time spent in MVPA (>?0.86). The agreement for the wear time assessment was excellent for 5 algorithms (Choi r?=?0.79; Troiano r?=?0.79; 20?min r?=?0.77; 30?min r?=?0.80; 60?min r?=?0.80). CONCLUSIONS:The choice of non-wear time rules may considerably affect the sedentary time assessment in youth. Using of appropriate data reduction decision in youth is needed to limit differences in associations between health outcomes and sedentary behaviors and may improve comparability for future studies. Based on our results, we recommend the use of the algorithm of 30?min of continuous zeros for defining non-wear time to improve the accuracy in assessing PA levels in youth. TRIAL REGISTRATION:NCT02844101 (retrospectively registered at July 13th 2016).

Dataset Information

Contrasting effects of physical wear on elution of two antibiotics from orthopedic cement.

Publications

Contrasting effects of physical wear on elution of two antibiotics from orthopedic cement.

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