Ontology highlight
ABSTRACT:
SUBMITTER: Zaman F
PROVIDER: S-EPMC3307731 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Zaman Farasat F Chrysis Dionisios D Huntjens Kirsten K Fadeel Bengt B Sävendahl Lars L
PloS one 20120319 3
Dexamethasone (Dexa) is a widely used glucocorticoid to treat inflammatory diseases; however, a multitude of undesired effects have been reported to arise from this treatment including osteoporosis, obesity, and in children decreased longitudinal bone growth. We and others have previously shown that glucocorticoids induce apoptosis in growth plate chondrocytes. Here, we hypothesized that Bax, a pro-apoptotic member of the Bcl-2 family, plays a key role in Dexa-induced chondrocyte apoptosis and b ...[more]