Ontology highlight
ABSTRACT:
SUBMITTER: Taylor AM
PROVIDER: S-EPMC3310385 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Taylor Alison M AM Humphries Jessica M JM White Richard M RM Murphey Ryan D RD Burns Caroline E CE Zon Leonard I LI
Experimental hematology 20111125 3
Disruption of ribosomal proteins is associated with hematopoietic phenotypes in cell culture and animal models. Mutations in ribosomal proteins are seen in patients with Diamond Blackfan anemia, a rare congenital disease characterized by red cell aplasia and distinctive craniofacial anomalies. A zebrafish screen uncovered decreased hematopoietic stem cells in embryos with mutations in ribosomal protein rps29. Here, we determined that rps29(-/-) embryos also have red blood cell defects and increa ...[more]