Ontology highlight
ABSTRACT:
SUBMITTER: English MA
PROVIDER: S-EPMC3328592 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
English Milton A MA Lei Lin L Blake Trevor T Wincovitch Stephen M SM Sood Raman R Azuma Mizuki M Hickstein Dennis D Liu P Paul PP
Developmental dynamics : an official publication of the American Association of Anatomists 20120329 5
<h4>Background</h4>Vertebrate hematopoiesis is a complex developmental process that is controlled by genes in diverse pathways. To identify novel genes involved in early hematopoiesis, we conducted an ENU (N-ethyl-N-nitrosourea) mutagenesis screen in zebrafish. The mummy (mmy) line was investigated because of its multiple hematopoietic defects.<h4>Results</h4>Homozygous mmy embryos lacked circulating blood cell types and were dead by 30 hr post-fertilization (hpf). The mmy mutants did not expres ...[more]