Ontology highlight
ABSTRACT:
SUBMITTER: Eisen HN
PROVIDER: S-EPMC3311345 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Eisen Herman N HN Hou Xun Helen XH Shen Chase C Wang Kaidi K Tanguturi Varsha Keelara VK Smith Crysela C Kozyrytska Katerina K Nambiar Lakshmi L McKinley Carol A CA Chen Jianzhu J Cohen Richard J RJ
Proceedings of the National Academy of Sciences of the United States of America 20120307 12
Algorithms derived from measurements of short-peptide (8-10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K(b), can bind well over 1 million different peptides with significant affinity (<500 nM), a level of ligand-binding promiscuity approaching the level of heat shock protein binding of unfolded proteins. MHC proteins can, nevertheless, discriminate between similar peptides and bind many of them with high (nanomolar) affinity. Some insi ...[more]