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Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation.

ABSTRACT: The regulation of gene expression represents one of the most fundamental of biologic processes that controls cellular proliferation, differentiation, and function. Recent technological advances in genome-wide annotation together with bioinformatic/computational analyses have contributed significantly to our understanding of transcriptional regulation at the epigenomic and regulomic levels. This perspective outlines the techniques that are being utilized and summarizes a few of the outcomes.

SUBMITTER: Pike JW

PROVIDER: S-EPMC3312753 | biostudies-other | 2011 Jun

REPOSITORIES: biostudies-other

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Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation.

Pike J Wesley JW

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110601 6

The regulation of gene expression represents one of the most fundamental of biologic processes that controls cellular proliferation, differentiation, and function. Recent technological advances in genome-wide annotation together with bioinformatic/computational analyses have contributed significantly to our understanding of transcriptional regulation at the epigenomic and regulomic levels. This perspective outlines the techniques that are being utilized and summarizes a few of the outcomes. ...[more]

PMID: 21611959

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