Ontology highlight
ABSTRACT:
SUBMITTER: Bomfim TR
PROVIDER: S-EPMC3314445 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Bomfim Theresa R TR Forny-Germano Leticia L Sathler Luciana B LB Brito-Moreira Jordano J Houzel Jean-Christophe JC Decker Helena H Silverman Michael A MA Kazi Hala H Melo Helen M HM McClean Paula L PL Holscher Christian C Arnold Steven E SE Talbot Konrad K Klein William L WL Munoz Douglas P DP Ferreira Sergio T ST De Felice Fernanda G FG
The Journal of clinical investigation 20120401 4
Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD). Although a connection between AD and diabetes has been suggested, a major unknown is the mechanism(s) by which insulin resistance in the brain arises in individuals with AD. Here, we show that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases. Brain tissue from humans with AD had elevated levels of IRS-1pSer and activated JNK, analogous to w ...[more]