Ontology highlight
ABSTRACT:
SUBMITTER: Sun XY
PROVIDER: S-EPMC3322889 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Sun Xu-Ying XY Wei Yu-Ping YP Xiong Yan Y Wang Xiao-Chuan XC Xie Ao-Ji AJ Wang Xiu-Lian XL Yang Yang Y Wang Qun Q Lu You-Ming YM Liu Rong R Wang Jian-Zhi JZ
The Journal of biological chemistry 20120210 14
Hyperphosphorylated tau is the major component of neurofibrillary tangles in Alzheimer disease (AD), and the tangle distribution largely overlaps with zinc-containing glutamatergic neurons, suggesting that zinc released in synaptic terminals may play a role in tau phosphorylation. To explore this possibility, we treated cultured hippocampal slices or primary neurons with glutamate or Bic/4-AP to increase the synaptic activity with or without pretreatment of zinc chelators, and then detected the ...[more]