Ontology highlight
ABSTRACT:
SUBMITTER: Hua S
PROVIDER: S-EPMC3331797 | biostudies-other | 2011 Sep
REPOSITORIES: biostudies-other
Hua Serenus S An Hyun Joo HJ Ozcan Sureyya S Ro Grace S GS Soares Stephanie S DeVere-White Ralph R Lebrilla Carlito B CB
The Analyst 20110721 18
Glycosylation is highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Glycan compositional profiling of human serum with mass spectrometry has already identified potential biomarkers for several types of cancer and diseases; however, composition alone does not fully describe glycan stereo- and regioisomeric diversity. The vast structural heterogeneity of glycans presents a formidable analytical challenge. We have developed a method to identif ...[more]