Ontology highlight
ABSTRACT:
SUBMITTER: de Groot RP
PROVIDER: S-EPMC333919 | biostudies-other | 1991 Apr
REPOSITORIES: biostudies-other
de Groot R P RP Pals C C Kruijer W W
Nucleic acids research 19910401 7
The proto-oncogene c-jun, a major component of transcription factor AP-1, is expressed at very low levels in undifferentiated embryonal carcinoma (EC) end embryonic stem (ES) cells. Retinoic acid (RA) induced differentiation causes a strong increase in the levels of c-jun mRNA. In this paper we report the cloning and characterization of the mouse c-jun promoter. Our results show that RA treatment causes a strong enhancement in c-jun promoter activity, an effect probably mediated by the RA-recept ...[more]