Ontology highlight
ABSTRACT:
SUBMITTER: Harper DS
PROVIDER: S-EPMC334013 | biostudies-other | 1992 Jul
REPOSITORIES: biostudies-other
Harper D S DS Fresco L D LD Keene J D JD
Nucleic acids research 19920701 14
We have characterized a recombinant Drosophila melanogaster RNA binding protein, D25, by virtue of its antigenic relationship to mammalian U1 and U2 small nuclear ribonucleoprotein (U snRNP) proteins. Sequence analysis revealed that D25 bears strong similarity to both the human U1 snRNP-A (U1-A) and U2 snRNP-B" (U2-B") proteins. However, at residues known to be critical for the RNA binding specificities of U1-A and U2-B" D25 sequence is more similar to U2-B". Using direct RNA binding assays D25 ...[more]