Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez G
PROVIDER: S-EPMC334418 | biostudies-other | 1992 Nov
REPOSITORIES: biostudies-other
Jiménez G G Gale K B KB Enver T T
Nucleic acids research 19921101 21
The human beta-globin LCR plays a key role in the transcriptional regulation of the beta-globin locus and comprises four erythroid specific DNase I hypersensitive sites, designated 5'HS1-4. We have now isolated genomic clones containing 5'HS3 and 5'HS4 of the mouse beta-globin LCR. 5'HS3 and 5'HS4 are located 15 kb and 22 kb upstream of the mouse epsilon y-globin gene, respectively. Sequence analysis of murine 5'HS3 and 5'HS4 reveals a significant degree of sequence conservation with their human ...[more]