Ontology highlight
ABSTRACT:
SUBMITTER: Arumugam PI
PROVIDER: S-EPMC2835044 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Arumugam Paritha I PI Higashimoto Tomoyasu T Urbinati Fabrizia F Modlich Ute U Nestheide Shawna S Xia Ping P Fox Catherine C Corsinotti Andrea A Baum Christopher C Malik Punam P
Molecular therapy : the journal of the American Society of Gene Therapy 20090825 11
Insertional mutagenesis by long terminal repeat (LTR) enhancers in gamma-retrovirus-based vectors (GVs) in clinical trials has prompted deeper investigations into vector genotoxicity. Experimentally, self-inactivating (SIN) lentivirus vectors (LVs) and GV containing internal promoters/enhancers show reduced genotoxicity, although strong ubiquitously-active enhancers dysregulate genes independent of vector type/design. Herein, we explored the genotoxicity of beta-globin (BG) locus control region ...[more]