Ontology highlight
ABSTRACT:
SUBMITTER: Buttrick GJ
PROVIDER: S-EPMC3346825 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Buttrick Graham J GJ Lancaster Theresa C TC Meadows John C JC Millar Jonathan B A JB
Journal of cell science 20120228 Pt 7
The fungal-specific heterodecameric outer kinetochore DASH complex facilitates the interaction of kinetochores with spindle microtubules. In budding yeast, where kinetochores bind a single microtubule, the DASH complex is essential, and phosphorylation of Dam1 by the Aurora kinase homologue, Ipl1, causes detachment of kinetochores from spindle microtubules. We demonstrate that in the distantly related fission yeast, where the DASH complex is not essential for viability and kinetochores bind mult ...[more]