Ontology highlight
ABSTRACT:
SUBMITTER: Kiang L
PROVIDER: S-EPMC2931602 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Kiang Lee L Heichinger Christian C Watt Stephen S Bähler Jürg J Nurse Paul P
Journal of cell science 20100824 Pt 18
To ensure equal replication of the genome in every eukaryotic cell cycle, replication origins fire only once each S phase and do not fire after passive replication. Failure in these controls can lead to local amplification, contributing to genome instability and the development of cancer. To identify features of replication origins important for such amplification, we have investigated origin firing and local genome amplification in the presence of excess helicase loaders Cdc18 and Cdt1 in fissi ...[more]