Ontology highlight
ABSTRACT:
SUBMITTER: Libby EA
PROVIDER: S-EPMC3358875 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Libby Elizabeth A EA Roggiani Manuela M Goulian Mark M
Proceedings of the National Academy of Sciences of the United States of America 20120423 19
It has long been hypothesized that subcellular positioning of chromosomal loci in bacteria may be influenced by gene function and expression state. Here we provide direct evidence that membrane protein expression affects the position of chromosomal loci in Escherichia coli. For two different membrane proteins, we observed a dramatic shift of their genetic loci toward the membrane upon induction. In related systems in which a cytoplasmic protein was produced, or translation was eliminated by muta ...[more]