Ontology highlight
ABSTRACT:
SUBMITTER: Shimizu Y
PROVIDER: S-EPMC3359886 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Shimizu Yoshiko Y Mullins Nicole N Blanchard Zannel Z Elshamy Wael M WM
Oncotarget 20120301 3
BRCA1/p220-assocaited and triple negative/basal-like (TN/BL) tumors are aggressive and incurable breast cancer diseases that share among other features the no/low BRCA1/p220 expression. Here we show that BRCA1/p220 silencing in normal human mammary epithelial (HME) cells reduces expression of two RNA-destabilizing proteins, namely AUF1 and pCBP2, both proteins bind and destabilize BRCA1-IRIS mRNA. BRCA1-IRIS overexpression in HME cells triggers expression of several TN/BL markers, e.g., cytokera ...[more]