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A Laplace pressure based microfluidic trap for passive droplet trapping and controlled release.


ABSTRACT: Here, we present a microfluidic droplet trap that takes advantage of the net Laplace pressure force generated when a droplet is differentially constricted. Mathematical simulations were first used to understand the working range of the component; followed by finite element modeling using the CFD software package to further characterize the behavior of the system. Controlled release of the trapped droplets is also demonstrated through both a mechanical method and a chemical method that manipulates the total pressure exerted on the trapped droplet. The unique design of this trapping device also provides the capability for selection of a single droplet from a train, as well as droplet fusion.

SUBMITTER: Simon MG 

PROVIDER: S-EPMC3365347 | biostudies-other | 2012 Mar

REPOSITORIES: biostudies-other

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