Ontology highlight
ABSTRACT:
SUBMITTER: Marcelin B
PROVIDER: S-EPMC3366832 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Marcelin Béatrice B Lugo Joaquin N JN Brewster Amy L AL Liu Zhiqiang Z Lewis Alan S AS McClelland Shawn S Chetkovich Dane M DM Baram Tallie Z TZ Anderson Anne E AE Becker Albert A Esclapez Monique M Bernard Christophe C
The Journal of biological chemistry 20120416 21
The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place. We report enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated ...[more]