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Pt-catalyzed cyclization/1,2-migration for the synthesis of indolizines, pyrrolones, and indolizinones.

ABSTRACT: Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates. [reaction: see text]

SUBMITTER: Smith CR

PROVIDER: S-EPMC3384527 | biostudies-other | 2007 Mar

REPOSITORIES: biostudies-other

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Pt-catalyzed cyclization/1,2-migration for the synthesis of indolizines, pyrrolones, and indolizinones.

Smith Cameron R CR Bunnelle Eric M EM Rhodes Allison J AJ Sarpong Richmond R

Organic letters 20070220 6

Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates. [reaction: see text] ...[more]

PMID: 17309277

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