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SUMOylation of Blimp-1 is critical for plasma cell differentiation.

ABSTRACT: Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

SUBMITTER: Ying HY

PROVIDER: S-EPMC3388782 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other

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SUMOylation of Blimp-1 is critical for plasma cell differentiation.

Ying Hsia-Yuan HY Su Shin-Tang ST Hsu Pang-Hung PH Chang Che-Chang CC Lin I-Ying IY Tseng Yu-Hsuan YH Tsai Ming-Daw MD Shih Hsiu-Ming HM Lin Kuo-I KI

EMBO reports 20120629 7

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression--correlating with a reduced interaction with a histone deacetylase, HDAC2--and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blim ...[more]

PMID: 22555612

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