Ontology highlight
ABSTRACT:
SUBMITTER: Masuda T
PROVIDER: S-EPMC3390833 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Masuda Tomoko T Itoh Katsuhiko K Higashitsuji Hiroaki H Higashitsuji Hisako H Nakazawa Noa N Sakurai Toshiharu T Liu Yu Y Tokuchi Hiromu H Fujita Takanori T Zhao Yan Y Nishiyama Hiroyuki H Tanaka Takashi T Fukumoto Manabu M Ikawa Masahito M Okabe Masaru M Fujita Jun J
Proceedings of the National Academy of Sciences of the United States of America 20120618 27
Cold-inducible RNA-binding protein (Cirp) was the first cold-shock protein identified in mammals. It is structurally quite different from bacterial cold-shock proteins and is induced in response to mild, but not severe, hypothermia. To clarify the physiological function of Cirp in vivo, we produced cirp-knockout mice. They showed neither gross abnormality nor defect in fertility, but the number of undifferentiated spermatogonia was significantly reduced and the recovery of spermatogenesis was de ...[more]