Ontology highlight
ABSTRACT:
SUBMITTER: Anon E
PROVIDER: S-EPMC3390890 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Anon Ester E Serra-Picamal Xavier X Hersen Pascal P Gauthier Nils C NC Sheetz Michael P MP Trepat Xavier X Ladoux Benoît B
Proceedings of the National Academy of Sciences of the United States of America 20120618 27
Fundamental biological processes such as morphogenesis and wound healing involve the closure of epithelial gaps. Epithelial gap closure is commonly attributed either to the purse-string contraction of an intercellular actomyosin cable or to active cell migration, but the relative contribution of these two mechanisms remains unknown. Here we present a model experiment to systematically study epithelial closure in the absence of cell injury. We developed a pillar stencil approach to create well-de ...[more]