Ontology highlight
ABSTRACT:
SUBMITTER: Sharma P
PROVIDER: S-EPMC5597329 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Sharma Puja P Ng Colin C Jana Aniket A Padhi Abinash A Szymanski Paige P Lee Jerry S H JSH Behkam Bahareh B Nain Amrinder S AS
Molecular biology of the cell 20170726 19
Cell emergence onto damaged or organized fibrous extracellular matrix (ECM) is a crucial precursor to collective cell migration in wound closure and cancer metastasis, respectively. However, there is a fundamental gap in our quantitative understanding of the role of local ECM size and arrangement in cell emergence-based migration and local gap closure. Here, using ECM-mimicking nanofibers bridging cell monolayers, we describe a method to recapitulate and quantitatively describe these in vivo beh ...[more]