11-[(E)-2-Fluoro-benzyl-idene]-8-(2-fluoro-phen-yl)-14-hy-droxy-6-thia-3,13-diaza-hepta-cyclo-[13.7.1.1(9,13).0(2,9).0(2,14).0(3,7).0(19,23)]tetra-cosa-1(22),15(23),16,18,20-pentaen-10-one.

ABSTRACT: In the title compound, C(34)H(26)F(2)N(2)O(2)S, an intra-molecular O-H?N hydrogen bond forms an S(5) ring motif. The piperidine ring adopts a chair conformation. The thia-zolidine ring and one of the pyrrolidine rings adopt envolope conformations with methyl-ene C atoms at the flap, whereas the other pyrrolidine ring adopts a half-chair conformation. The fluoro-substituted benzene rings form dihedral angles of 32.25?(10) and 38.27?(10)°, respectively, with the mean plane of the dihydro-acenaphthyl-ene ring system [maximum deviation = 0.043?(2)?Å]. The dihedral angle between the fluoro-substituted benzene rings is 64.13?(14)°. In the crystal, mol-ecules are linked by weak C-H?O, C-H?F and C-H?S hydrogen bonds into a three-dimensional network.

SUBMITTER: Kumar RS 

PROVIDER: S-EPMC3393908 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other