Ontology highlight
ABSTRACT:
SUBMITTER: Chinenov Y
PROVIDER: S-EPMC3406827 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Chinenov Yurii Y Gupte Rebecca R Dobrovolna Jana J Flammer Jamie R JR Liu Bill B Michelassi Francesco E FE Rogatsky Inez I
Proceedings of the National Academy of Sciences of the United States of America 20120702 29
Inhibition of cytokine gene expression by the hormone-activated glucocorticoid receptor (GR) is the key component of the anti-inflammatory actions of glucocorticoids, yet the underlying molecular mechanisms remain obscure. Here we report that glucocorticoid repression of cytokine genes in primary macrophages is mediated by GR-interacting protein (GRIP)1, a transcriptional coregulator of the p160 family, which is recruited to the p65-occupied genomic NFκB-binding sites in conjunction with ligande ...[more]