Ontology highlight
ABSTRACT:
SUBMITTER: Gali Ramamoorthy T
PROVIDER: S-EPMC4703903 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Gali Ramamoorthy Thanuja T Laverny Gilles G Schlagowski Anna-Isabel AI Zoll Joffrey J Messaddeq Nadia N Bornert Jean-Marc JM Panza Salvatore S Ferry Arnaud A Geny Bernard B Metzger Daniel D
Nature communications 20151217
The transcriptional coregulators PGC-1α and PGC-1β modulate the expression of numerous partially overlapping genes involved in mitochondrial biogenesis and energetic metabolism. The physiological role of PGC-1β is poorly understood in skeletal muscle, a tissue of high mitochondrial content to produce ATP levels required for sustained contractions. Here we determine the physiological role of PGC-1β in skeletal muscle using mice, in which PGC-1β is selectively ablated in skeletal myofibres at adul ...[more]