Ontology highlight
ABSTRACT:
SUBMITTER: Murugan A
PROVIDER: S-EPMC3409783 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
Murugan Arvind A Huse David A DA Leibler Stanislas S
Proceedings of the National Academy of Sciences of the United States of America 20120711 30
Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and microtubule growth which share some of the features described above. Our analogy relates the statistics of growth and shrinkage of microtubules in physical space to the cycling of interm ...[more]