Stochastic optical active rheology.
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ABSTRACT: We demonstrate a stochastic based method for performing active rheology using optical tweezers. By monitoring the displacement of an embedded particle in response to stochastic optical forces, a rapid estimate of the frequency dependent shear moduli of a sample is achieved in the range of 10(-1)-10(3) Hz. We utilize the method to probe linear viscoelastic properties of hydrogels at varied cross-linker concentrations. Combined with fluorescence imaging, our method demonstrates non-linear changes of bond strength between T cell receptors and an antigenic peptide due to force-induced cell activation.
SUBMITTER: Lee H
PROVIDER: S-EPMC3411558 | biostudies-other | 2012 Jul
REPOSITORIES: biostudies-other
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