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New MLSB resistance gene erm(43) in Staphylococcus lentus.

ABSTRACT: The search for a specific rRNA methylase motif led to the identification of the new macrolide, lincosamide, and streptogramin B resistance gene erm(43) in Staphylococcus lentus. An inducible resistance phenotype was demonstrated by cloning and expressing erm(43) and its regulatory region in Staphylococcus aureus. The erm(43) gene was detected in two different DNA fragments, of 6,230 bp and 1,559 bp, that were each integrated at the same location in the chromosome in several S. lentus isolates of human, dog, and chicken origin.

SUBMITTER: Schwendener S

PROVIDER: S-EPMC3421867 | biostudies-other | 2012 Sep

REPOSITORIES: biostudies-other

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New MLSB resistance gene erm(43) in Staphylococcus lentus.

Schwendener Sybille S Perreten Vincent V

Antimicrobial agents and chemotherapy 20120625 9

The search for a specific rRNA methylase motif led to the identification of the new macrolide, lincosamide, and streptogramin B resistance gene erm(43) in Staphylococcus lentus. An inducible resistance phenotype was demonstrated by cloning and expressing erm(43) and its regulatory region in Staphylococcus aureus. The erm(43) gene was detected in two different DNA fragments, of 6,230 bp and 1,559 bp, that were each integrated at the same location in the chromosome in several S. lentus isolates of ...[more]

PMID: 22733067

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