Ontology highlight
ABSTRACT:
SUBMITTER: Devogelaere B
PROVIDER: S-EPMC3421868 | biostudies-other | 2012 Sep
REPOSITORIES: biostudies-other
Antimicrobial agents and chemotherapy 20120618 9
Hepatitis C virus (HCV) infection is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. There remains an unmet medical need for efficacious and safe direct antivirals with complementary modes of action for combination in treatment regimens to deliver a high cure rate with a short duration of treatment for HCV patients. Here we report the in vitro inhibitory activity, mode of action, binding kinetics, and resistance profile of TM ...[more]