Ontology highlight
ABSTRACT:
SUBMITTER: Charlier C
PROVIDER: S-EPMC3430679 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Charlier Carole C Agerholm Jorgen Steen JS Coppieters Wouter W Karlskov-Mortensen Peter P Li Wanbo W de Jong Gerben G Fasquelle Corinne C Karim Latifa L Cirera Susanna S Cambisano Nadine N Ahariz Naima N Mullaart Erik E Georges Michel M Fredholm Merete M
PloS one 20120829 8
Fertility is one of the most important traits in dairy cattle, and has been steadily declining over the last decades. We herein use state-of-the-art genomic tools, including high-throughput SNP genotyping and next-generation sequencing, to identify a 3.3 Kb deletion in the FANCI gene causing the brachyspina syndrome (BS), a rare recessive genetic defect in Holstein dairy cattle. We determine that despite the very low incidence of BS (<1/100,000), carrier frequency is as high as 7.4% in the Holst ...[more]