Ontology highlight
ABSTRACT:
SUBMITTER: Sartelet A
PROVIDER: S-EPMC3305398 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Sartelet Arnaud A Druet Tom T Michaux Charles C Fasquelle Corinne C Géron Sarah S Tamma Nico N Zhang Zhiyan Z Coppieters Wouter W Georges Michel M Charlier Carole C
PLoS genetics 20120315 3
We report association mapping of a locus on bovine chromosome 3 that underlies a Mendelian form of stunted growth in Belgian Blue Cattle (BBC). By resequencing positional candidates, we identify the causative c124-2A>G splice variant in intron 1 of the RNF11 gene, for which all affected animals are homozygous. We make the remarkable observation that 26% of healthy Belgian Blue animals carry the corresponding variant. We demonstrate in a prospective study design that approximately one third of ho ...[more]